Marquez memimpin dalam latihan bebas pertama (FP1) di Austin, mengalahkan penantang terdekat Valentino Rossi dengan selisih 0.396 detik.
Marquez berada diposisi pertama hampir sepanjang sesi 45 menit fp1 di Circuit of the Americas. Sirkuit yang dimana pembalap Spanyol tersebut tak terkalahkan, raihan catatan waktu terbaiknya untuk fp1 adalah 2 m 05.530 detik.
| Pos. | # | Rider | Bike | Time | Gap |
|---|---|---|---|---|---|
| 1 | 93 | Marc Marquez | Honda | 2’05.530 | |
| 2 | 46 | Valentino Rossi | Yamaha | 2’05.926 | 0.396 |
| 3 | 25 | Maverick Viñales | Yamaha | 2’06.257 | 0.727 |
| 4 | 99 | Jorge Lorenzo | Ducati | 2’06.480 | 0.950 |
| 5 | 35 | Cal Crutchlow | Honda | 2’06.539 | 1.009 |
| 6 | 4 | Andrea Dovizioso | Ducati | 2’06.734 | 1.204 |
| 7 | 30 | Takaaki Nakagami | Honda | 2’07.010 | 1.480 |
| 8 | 29 | Andrea Iannone | Suzuki | 2’07.093 | 1.563 |
| 9 | 5 | Johann Zarco | Yamaha | 2’07.124 | 1.594 |
| 10 | 42 | Alex Rins | Suzuki | 2’07.211 | 1.681 |
| 11 | 41 | Aleix Espargaro | Aprilia | 2’07.431 | 1.901 |
| 12 | 45 | Scott Redding | Aprilia | 2’07.459 | 1.929 |
| 13 | 9 | Danilo Petrucci | Ducati | 2’07.523 | 1.993 |
| 14 | 53 | Tito Rabat | Ducati | 2’07.662 | 2.132 |
| 15 | 19 | Alvaro Bautista | Ducati | 2’07.874 | 2.344 |
| 16 | 44 | Pol Espargaro | KTM | 2’07.948 | 2.418 |
| 17 | 38 | Bradley Smith | KTM | 2’08.161 | 2.631 |
| 18 | 12 | Thomas Luthi | Honda | 2’08.234 | 2.704 |
| 19 | 21 | Franco Morbidelli | Honda | 2’08.372 | 2.842 |
| 20 | 55 | Hafizh Syahrin | Yamaha | 2’08.819 | 3.289 |
| 21 | 26 | Dani Pedrosa | Honda | 2’09.111 | 3.581 |
| 22 | 17 | Karel Abraham | Ducati | 2’09.327 | 3.797 |
| 23 | 43 | Jack Miller | Ducati | 2’09.708 | 4.178 |
| 24 | 10 | Xavier Simeon | Ducati | 2’10.426 | 4.896 |
