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Andrea Dovizoso mengalahkan rekan setimnya Jorge Lorenzo dengan selisih 0,160 detik pada FP2 MotoGP San Marino Misano 2018, sementara pembalap tuan rumah Valentino Rossi berhasil masuk 10 besar setelah terlempar dari FP1.
Berikut hasil lengkap FP2 MotoGP San Marino Misano 2018:
| Pos | Driver | Team | Time | Gap |
|---|---|---|---|---|
| 1 | Andrea Dovizioso | Ducati Team | 1:32.198 | |
| 2 | Jorge Lorenzo | Ducati Team | 1:32.358 | 0.160 |
| 3 | Cal Crutchlow | LCR Honda | 1:32.385 | 0.187 |
| 4 | Maverick Vinales | Yamaha MotoGP | 1:32.411 | 0.213 |
| 5 | Marc Marquez | Honda Team | 1:32.537 | 0.339 |
| 6 | Danilo Petrucci | Pramac Racing | 1:32.722 | 0.524 |
| 7 | Alex Rins | Suzuki Ecstar | 1:32.775 | 0.577 |
| 8 | Valentino Rossi | Yamaha MotoGP | 1:32.786 | 0.588 |
| 9 | Franco Morbidelli | Marc VDS | 1:32.980 | 0.782 |
| 10 | Johann Zarco | Yamaha Tech 3 | 1:32.985 | 0.787 |
| 11 | Dani Pedrosa | Honda Team | 1:32.999 | 0.801 |
| 12 | Michele Pirro | Ducati Team | 1:33.005 | 0.807 |
| 13 | Alvaro Bautista | Angel Nieto Team | 1:33.153 | 0.955 |
| 14 | Jack Miller | Pramac Racing | 1:33.193 | 0.995 |
| 15 | Takaaki Nakagami | LCR Honda | 1:33.274 | 1.076 |
| 16 | Andrea Iannone | Suzuki Ecstar | 1:33.423 | 1.225 |
| 17 | Scott Redding | Aprilia Racing | 1:33.517 | 1.319 |
| 18 | Aleix Espargaro | Aprilia Racing | 1:33.654 | 1.456 |
| 19 | Stefan Bradl | Honda Team | 1:33.665 | 1.467 |
| 20 | Bradley Smith | KTM Racing | 1:33.815 | 1.617 |
| 21 | Karel Abraham | Angel Nieto Team | 1:33.878 | 1.680 |
| 22 | Xavier Simeon | Avintia Racing | 1:33.896 | 1.698 |
| 23 | Thomas Luthi | Marc VDS | 1:34.278 | 2.080 |
| 24 | Pol Espargaro | KTM Racing | 1:34.461 | 2.263 |
| 25 | Hafizh Syahrin | Yamaha Tech 3 | 1:34.539 | 2.341 |
| 26 | Christophe Ponsson | Avintia Racing | 1:38.154 | 5.956 |