Jorge Lorenzo menghapus rekor lap Misano untuk merebut pole MotoGP San Marino, sementara pemimpin kejuaraan Marc Marquez jatuh.
Berikut hasil lengkap kualifikasi MotoGP San Marino Misano 2018:
| Pos | Rider | Team | Time | Gap |
|---|---|---|---|---|
| 1 | Jorge Lorenzo | Ducati Team | 1:31.629 | |
| 2 | Jack Miller | Pramac Racing | 1:31.916 | 0.287 |
| 3 | Maverick Vinales | Yamaha MotoGP | 1:31.950 | 0.321 |
| 4 | Andrea Dovizioso | Ducati Team | 1:32.003 | 0.374 |
| 5 | Marc Marquez | Honda Team | 1:32.016 | 0.387 |
| 6 | Cal Crutchlow | LCR Honda | 1:32.025 | 0.396 |
| 7 | Valentino Rossi | Yamaha MotoGP | 1:32.028 | 0.399 |
| 8 | Danilo Petrucci | Pramac Racing | 1:32.136 | 0.507 |
| 9 | Johann Zarco | Yamaha Tech 3 | 1:32.250 | 0.621 |
| 10 | Alex Rins | Suzuki Ecstar | 1:32.338 | 0.709 |
| 11 | Dani Pedrosa | Honda Team | 1:32.369 | 0.740 |
| 12 | Franco Morbidelli | Marc VDS | ||
| 13 | Andrea Iannone | Suzuki Ecstar | 1:32.566 | |
| 14 | Michele Pirro | Ducati Team | 1:32.624 | |
| 15 | Alvaro Bautista | Angel Nieto Team | 1:32.792 | |
| 16 | Aleix Espargaro | Aprilia Racing | 1:33.084 | |
| 17 | Bradley Smith | KTM Racing | 1:33.085 | |
| 18 | Stefan Bradl | Honda Team | 1:33.361 | |
| 19 | Takaaki Nakagami | LCR Honda | 1:33.437 | |
| 20 | Pol Espargaro | KTM Racing | 1:33.502 | |
| 21 | Scott Redding | Aprilia Racing | 1:33.572 | |
| 22 | Xavier Simeon | Avintia Racing | 1:33.705 | |
| 23 | Thomas Luthi | Marc VDS | 1:33.755 | |
| 24 | Karel Abraham | Angel Nieto Team | 1:33.812 | |
| 25 | Hafizh Syahrin | Yamaha Tech 3 | 1:34.080 | |
| 26 | Christophe Ponsson | Avintia Racing | 1:37.180 |
