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Pembalap Pramac Ducati, Danilo Petrucci menduduki sesi latihan bebas ke-2 dalam kondisi hujan di MotoGP Valencia 2018.
Petrucci mengalahkan Marc Marquez yang sebelumnya memuncaki FP1, disusul Valentino Rossi diposisi ke-3.
Johann Zarco mengalami kecelakaan di tikungan ke-12 yang membuat bendera merah dikibarkan sekitar 10 menit. Berikut hasil lengkap FP2 MotoGP Valencia 2018:
| Pos | Rider | Team | Time | Gap | Laps |
|---|---|---|---|---|---|
| 1 | Danilo Petrucci | Pramac Ducati | 1m41.318s | – | 14 |
| 2 | Marc Marquez | Honda | 1m41.725s | 0.407s | 21 |
| 3 | Valentino Rossi | Yamaha | 1m42.081s | 0.763s | 16 |
| 4 | Andrea Iannone | Suzuki | 1m42.365s | 1.047s | 14 |
| 5 | Aleix Espargaro | Aprilia | 1m42.385s | 1.067s | 7 |
| 6 | Pol Espargaro | KTM | 1m42.655s | 1.337s | 14 |
| 7 | Maverick Vinales | Yamaha | 1m42.746s | 1.428s | 20 |
| 8 | Scott Redding | Aprilia | 1m42.857s | 1.539s | 18 |
| 9 | Bradley Smith | KTM | 1m43.009s | 1.691s | 17 |
| 10 | Alex Rins | Suzuki | 1m43.051s | 1.733s | 20 |
| 11 | Xavier Simeon | Avintia Ducati | 1m43.113s | 1.795s | 5 |
| 12 | Andrea Dovizioso | Ducati | 1m43.250s | 1.932s | 21 |
| 13 | Jack Miller | Pramac Ducati | 1m43.409s | 2.091s | 5 |
| 14 | Hafizh Syahrin | Tech3 Yamaha | 1m43.727s | 2.409s | 21 |
| 15 | Jorge Lorenzo | Ducati | 1m43.798s | 2.480s | 13 |
| 16 | Alvaro Bautista | Aspar Ducati | 1m43.844s | 2.526s | 17 |
| 17 | Takaaki Nakagami | LCR Honda | 1m43.846s | 2.528s | 22 |
| 18 | Franco Morbidelli | MVDS Honda | 1m43.854s | 2.536s | 19 |
| 19 | Thomas Luthi | MVDS Honda | 1m43.858s | 2.540s | 15 |
| 20 | Johann Zarco | Tech3 Yamaha | 1m44.261s | 2.943s | 8 |
| 21 | Michele Pirro | Ducati | 1m44.681s | 3.363s | 14 |
| 22 | Stefan Bradl | LCR Honda | 1m44.732s | 3.414s | 3 |
| 23 | Karel Abraham | Aspar Ducati | 1m45.260s | 3.942s | 6 |
| 24 | Dani Pedrosa | Honda | 1m45.401s | 4.083s | 5 |
| 25 | Jordi Torres | Avintia Ducati | 1m45.975s | 4.657s | 16 |